Vitamin D3, K2, osteocalcin and Matrix GLA protein #vitaminD #vitaminK2 [jFiJ9oLV1]
Vitamin D3, K2, osteocalcin and Matrix GLA protein #vitaminD #vitaminK2 [jFiJ9oLV1]
Test your Vitamin D2 and D3 levels (home test for the UK) https://neovos.com/product/vitamin-d-test/ Use code onlinecoach10 for 10% off Vitamin D3, K2, osteocalcin and Matrix GLA protein Hey there! So, you're wondering about the conflicting effects of vitamin D3 and calcium on health, right? It's a bit of a head-scratcher, isn't it? [citation:6] Studies have shown that high doses of vitamin D can sometimes lead to too much calcium in the blood, increasing the risk of hardening of the arteries, like in atherosclerotic heart disease. [citation:1][citation:2] On the other hand, some studies have found that calcium supplementation can improve bone density, while others suggest it might increase the risk of heart and artery problems. So, how can vitamin D3 cause hypercalcemia (too much calcium in the blood) if some people have normal calcium levels even with high D3? [citation:6] Well, it turns out that the commonly accepted nutritional advice and medical guidelines might not be entirely accurate. Trevor Stain from the Royal College of Physicians in London even called D3 supplementation "extremely dangerous" due to the risk of hypercalcemia, but that seems to be an overstatement based on limited evidence. The thing is, calcium in the bones is perfectly normal, while calcium in the arteries is problematic. [citation:3][citation:4] Vitamin D3 and K2 play a crucial role in calcium metabolism, working together to ensure that calcium is efficiently absorbed and directed to the right places in the body, like bones and teeth, and away from soft tissues like arteries. When you take vitamin D3, it enhances calcium absorption by increasing the expression of calcium-binding proteins in the intestine. [citation:3] It also helps maintain calcium levels in the blood by promoting calcium reabsorption in the kidneys and potentially mobilizing calcium from bones when necessary. [citation:3] This is where K2 comes in - it helps direct the absorbed calcium to the right places. Vitamin D3 influences the expression of proteins like osteocalcin and Matrix GLA protein (MGP), which depend on K2 to function properly. [citation:3] Osteocalcin is synthesized by osteoblasts, the cells responsible for forming bone matrix, and vitamin D3 binds to the vitamin D receptor (VDR) to regulate this process. So, while it's true that high doses of vitamin D3 can sometimes cause hypercalcemia, it's not a universal rule. The key is to ensure that you have adequate levels of both vitamin D3 and K2 to maintain proper calcium balance in your body. It's always best to consult with a healthcare professional to determine the right supplementation plan for your individual needs. If you want to dig deeper into this then there is so much more to it. Bone is an endocrine organ and the role of osteocalcin in moving calcium to the bone is not as clear cut as you may think. Without adequate vitamin K2 osteocalcin will not be activated. The same can be said of Matrix GLA proteins, without vitamin K2 they seem to not be activated so they can’t fully play their role in preventing calcium entering the lining of the arteries. But then there is the carboxylation issue. This revolves around undercarboxylated osteocalcin that is released from the bone and the downstream effects this has, particularly in insulin management and even blood sugar control. To muddy the waters further there have been mouse studies using ‘knock-out’ osteocalcin mice. Basically they don’t have osteocalcin in their system and the impact on bone health was not as deleterious as expected. Hopefully this gives you some ‘rabbit-holes’ to go down. Good day. More details can be found at www.theukcarnivore.com Citations 1. Voulgaridou G, Papadopoulou SK, Detopoulou P, et al. Vitamin D and Calcium in Osteoporosis, and the Role of Bone Turnover Markers: A Narrative Review of Recent Data from RCTs. Diseases. 2023;11(1):29. Published 2023 Feb 8. doi:10.3390/diseases11010029 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944083/ 2. Laird E, Ward M, McSorley E, Strain JJ, Wallace J. Vitamin D and bone health: potential mechanisms. Nutrients. 2010;2(7):693-724. doi:10.3390/nu2070693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257679/ 3. https://ajcn.nutrition.org/article/S0002-9165(23)24133-7/fulltext 4. Bouillon, R., Manousaki, D., Rosen, C. et al. The health effects of vitamin D supplementation: evidence from human studies. Nat Rev Endocrinol 18, 96–110 (2022). https://doi.org/10.1038/s41574-021-00593-z 5. https://chrismasterjohnphd.substack.com/p/the-ultimate-vitamin-k2-resource 6. Etienne Cavalier, Konstantinos Makris, Annemieke C Heijboer, Markus Herrmann, Jean-Claude Souberbielle, Vitamin D: Analytical Advances, Clinical Impact, and Ongoing Debates on Health Perspectives, Clinical Chemistry, 2024;, hvae056, https://doi.org/10.1093/clinchem/hvae056
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